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. Author manuscript; available in PMC: 2011 Jan 15.
Published in final edited form as: Bioorg Med Chem Lett. 2009 Nov 18;20(2):665. doi: 10.1016/j.bmcl.2009.11.056

Table 3.

Effects of amide modifications on transcription and cytotoxicity in transfected PC-3 cellsa

graphic file with name nihms163359t3.jpg
Cmpd T IC50SRE.L
(µM)		 % inh SRE.L
(10, 100 µM)		 % inh pRL-TK
(10, 100 µM)		 % inh WST-1
(10, 100 µM)
4a -CONHCH2CH2CONH- 38 38, 64 0, 22 0, 10
4e -CONHCH2CH2CON(Me)- >100
4f -CONHCH2CH2CONHCH2 >100
8 -CONHCH2CH2CH2NH- 5.1 70, 80 37, 35 0, 11
11 -CH2NHCH2CH2CONH- 8.1 64, 100 12, 91 0, 92
12 -CH2NHCH2CH2CH2NH- 9.1 65, 100 6, 90 0, 89
a

Assays defined in Table 1.