. Author manuscript; available in PMC: 2011 Jan 15.

Published in final edited form as: Bioorg Med Chem Lett. 2009 Nov 18;20(2):665. doi: 10.1016/j.bmcl.2009.11.056

Table 6.

Effects of new analogs on cell invasion and cytotoxicity^a

Cmpd	% inh invasion^b (10 µM)	% inh WST-1^c (10 µM)	% inh invasion^b (100 µM)	% inh WST-1^c (100 µM)
1	71	54
4a	13	0	62	28
4b	14	0	75	38
4c	6	0	31	1
4d	15	0	25	1
4g	20	0	72	23
4h	14	0	79	36
4i	12	0	78	44
4m	63	31	86	70
4n	2	0	0	1
4p	0	0	0	0
5a	50	14	88	78
8	54	0	84	27
11	47	0	96	95
12	30	0	86	97
13	18	0	8	0
14	3	0	26	0
20	18	0	56	0

For assay descriptions, see Ref 21.

Inhibition of invasion by cultured PC-3 cells into a Matrigel matrix.

Inhibition of mitochondrial metabolism of WST-1.

Cmpd	% inh invasion^b (10 µM)	% inh WST-1^c (10 µM)	% inh invasion^b (100 µM)	% inh WST-1^c (100 µM)
1	71	54
4a	13	0	62	28
4b	14	0	75	38
4c	6	0	31	1
4d	15	0	25	1
4g	20	0	72	23
4h	14	0	79	36
4i	12	0	78	44
4m	63	31	86	70
4n	2	0	0	1
4p	0	0	0	0
5a	50	14	88	78
8	54	0	84	27
11	47	0	96	95
12	30	0	86	97
13	18	0	8	0
14	3	0	26	0
20	18	0	56	0

Cmpd	% inh invasion^b (10 µM)	% inh WST-1^c (10 µM)	% inh invasion^b (100 µM)	% inh WST-1^c (100 µM)
1	71	54
4a	13	0	62	28
4b	14	0	75	38
4c	6	0	31	1
4d	15	0	25	1
4g	20	0	72	23
4h	14	0	79	36
4i	12	0	78	44
4m	63	31	86	70
4n	2	0	0	1
4p	0	0	0	0
5a	50	14	88	78
8	54	0	84	27
11	47	0	96	95
12	30	0	86	97
13	18	0	8	0
14	3	0	26	0
20	18	0	56	0

Cmpd	% inh invasion^b (10 µM)	% inh WST-1^c (10 µM)	% inh invasion^b (100 µM)	% inh WST-1^c (100 µM)
1	71	54
4a	13	0	62	28
4b	14	0	75	38
4c	6	0	31	1
4d	15	0	25	1
4g	20	0	72	23
4h	14	0	79	36
4i	12	0	78	44
4m	63	31	86	70
4n	2	0	0	1
4p	0	0	0	0
5a	50	14	88	78
8	54	0	84	27
11	47	0	96	95
12	30	0	86	97
13	18	0	8	0
14	3	0	26	0
20	18	0	56	0