Table 2.
Deaths and Mortality Rates from Specific Medical Conditions, by Practice Randomization Group Assignment and Stratified by Baseline Depression Status*
| Medical Condition | Intervention Group | Usual Care Group | ||
|---|---|---|---|---|
| Deaths, n |
Mortality Rate (95% CI), n/1000 person-years |
Deaths, n |
Mortality Rate (95% CI), n/1000 person-years |
|
| All patients with depression (n = 599) | 60 | 44.7 (34.1–57.6) | 55 | 49.7 (37.4–64.6) |
| Cardiovascular disease | 23 | 17.1 (10.9–25.7) | 15 | 13.5 (7.6–22.3) |
| Stroke | 3 | 2.2 (0.5–6.5) | 4 | 3.6 (1.0–9.2) |
| Cancer | 12 | 8.9 (4.6–15.6) | 18 | 16.3 (9.6–25.7) |
| Respiratory disease | 8 | 6.0 (2.6–11.7) | 3 | 2.7 (0.6–7.9) |
| Accident | 2 | 1.5 (0.2–5.4) | 2 | 1.8 (0.2–6.5) |
| Suicide | 1 | 0.7 (0.0–4.2) | 0 | 0.0 (0.0–3.3) |
| Other diseases | 11 | 8.2 (4.1–14.7) | 13 | 11.7 (6.3–20.1) |
| Patients with major depression disorder (n = 396) | 39 | 43.6 (31.0–59.6) | 38 | 52.3 (37.0–71.8) |
| Cardiovascular disease | 16 | 17.9 (10.2–29.1) | 8 | 11.0 (4.8–21.7) |
| Stroke | 2 | 2.2 (0.3–8.1) | 2 | 2.8 (0.3–9.9) |
| Cancer | 8 | 8.9 (3.9–17.6) | 15 | 20.6 (11.6–34.1) |
| Respiratory disease | 5 | 5.6 (1.8–13.0) | 2 | 2.8 (0.3–9.9) |
| Accident | 1 | 1.1 (0.0–6.2) | 1 | 1.4 (0.0–7.7) |
| Suicide | 0 | 0.0 (0.0–4.1) | 0 | 0.0 (0.0–5.1) |
| Other diseases | 7 | 7.8 (3.1–16.1) | 10 | 13.8 (6.6–25.3) |
| Patients with clinically significant minor depression (n = 203) | 21 | 46.9 (29.1–71.7) | 17 | 44.6 (26.0–71.4) |
| Cardiovascular disease | 7 | 15.6 (6.3–32.2) | 7 | 18.4 (7.4–37.9) |
| Stroke | 1 | 2.2 (0.1–12.5) | 2 | 5.2 (0.6–19.0) |
| Cancer | 4 | 8.9 (2.4–22.9) | 3 | 7.9 (1.6–23.0) |
| Respiratory disease | 3 | 6.7 (1.4–19.6) | 1 | 2.6 (0.1–14.6) |
| Accident | 1 | 2.2 (0.1–12.5) | 1 | 2.6 (0.1–14.6) |
| Suicide | 1 | 2.2 (0.1–12.5) | 0 | 0.0 (0.0–9.7) |
| Other diseases | 4 | 8.9 (2.4–22.9) | 3 | 7.9 (1.6–23.0) |
| Patients without depression (n = 627) | 52 | 41.7 (31.2–54.7) | 56 | 38.0 (28.7–49.3) |
| Cardiovascular disease | 20 | 16.1 (9.8–24.8) | 19 | 12.9 (7.8–20.1) |
| Stroke | 3 | 2.4 (0.5–7.0) | 4 | 2.7 (0.7–6.9) |
| Cancer | 12 | 9.6 (5.0–16.8) | 17 | 11.5 (6.7–18.4) |
| Respiratory disease | 4 | 3.2 (0.9–8.2) | 5 | 3.4 (1.1–7.9) |
| Accident | 3 | 2.4 (0.5–7.0) | 0 | 0.0 (0.0–2.5) |
| Suicide | 0 | 0.0 (0.0–3.0) | 0 | 0.0 (0.0–2.5) |
| Other diseases | 10 | 8.0 (3.8–14.8) | 11 | 7.5 (3.7–13.3) |
*
Data from the Prevention of Suicide in Primary Care Elderly: Collaborative Trial (1999 to 2004) (14).