Table 2.
Treatment-related adverse events (n = 24 patients)
| Adverse Events | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
|---|---|---|---|---|
| Blood/Bone Marrow | ||||
| Anemia | 2 | 1 | 1 | |
| Thrombocytopenia | 2 | 1 | ||
| Cardiovascular | ||||
| CNS cerebrovascular ischemia | 1 | |||
| Hypertension | 3 | |||
| Thrombosis/embolism (vascular access-related) | 1 | 1 | ||
| Constitutional symptoms | ||||
| Fatigue | 10 | 2 | 2 | |
| Weight loss | 3 | 2 | ||
| Dermatology/skin | ||||
| Hand-foot skin reaction | 1 | 9 | 3 | |
| Rash/desquamation | 11 | 3 | 1 | |
| Gastrointestinal | ||||
| Diarrhea | 6 | 2 | ||
| Nausea | 1 | 1 | 1 | |
| Infection | 1 | |||
| Metabolic/Laboratory | ||||
| ALT,SGPT | 6 | 2 | ||
| AST,SGOT | 8 | 1 | ||
| Alkaline phosphatase | 1 | 4 | 1 | |
| Hyperkalemia | 1 | |||
| Hyponatremia | 1 | 1 | ||
| Hypophosphatemia | 3 | 5 | ||
| Pain | ||||
| Musculoskeletal | 3 | 7 | ||
| Throat/larynx | 1 | 1 | ||
| Pulmonary/Upper respiratory | ||||
| Voice changes | 3 |