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. 2009 Oct 20;18(2):285–294. doi: 10.1038/mt.2009.232

Figure 1.

Figure 1

Rationale for the construction of Vstat120 expressing OV. Increased CYR61 and reduced TSP-1 expression in the tumor microenvironment upon OV treatment. Increased CYR61 would lead to integrin-mediated activation of endothelial cells resulting in angiogenesis. Reduction in antiangiogenic TSP-1 would further tilt the scale toward increased angiogenesis. Vstat120 expression by RAMBO would counter both of these effects and inhibit angiogenesis of the residual disease. OV, oncolytic virus; RAMBO, Rapid Antiangiogenesis Mediated By Oncolytic virus; TSP-1, thrombospondin 1; Vstat120, vasculostatin.