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. 2009 Oct 20;18(2):285–294. doi: 10.1038/mt.2009.232

Figure 3.

Figure 3

Cytotoxicity of RAMBO and HSVQ toward glioma cell lines and normal human astrocytes. (a) The in vitro cytotoxicity of RAMBO was compared to HSVQ in LN229, U87ΔEGFR, Gli36ΔEGFR-H2B-RFP, and U343 cells. The percentage of viable cells relative to uninfected cells was measured by crystal violet assay on day 3. (b) Cytotoxicity of RAMBO and HSVQ toward normal human astrocytes (NHA). NHA cells were infected with HSVQ or RAMBO at the indicated MOIs. After 72 hours, the percent survival was assessed by a standard colorimetric crystal violet assay. Data shown are the mean ± SD % survival relative to uninfected cells. Note, no significant difference in the number of viable cells infected with HSVQ or RAMBO at each MOI. MOI, multiplicity of infection; RAMBO, Rapid Antiangiogenesis Mediated By Oncolytic virus; Vstat120, vasculostatin.