Table 2.

Summary of Population Pharmacokinetic Parameters

Parameter	NONMEM Estimate	Mean Bootsrap Estimate	Bootstrap SEE	Bootstrap 95% CI	NONMEM IIV (%)

CL_am
Plasma (L/hr/m²)^*	107	106	8.41	90.3 – 123	0.15 (38)
Plasma (L/hr)	107	106	11.5	86.3 – 130	0.31 (56)
Blood (L/hr/m²)^*	136	133	10.7	113 – 155	0.13 (36)
Blood (L/hr)	135	132	14.2	105 – 160	0.3 (55)
VD
Plasma (L/m²)^*	5.53	5.51	0.55	4.53 – 6.60	0.12 (34)
Plasma (L)	5.62	5.51	0.72	4.36 – 7.03	0.32 (56)
Blood (L/m²)^*	7.23	6.97	1.04	4.73 – 8.71	0.08 (28)
Blood (L)	7.14	6.84	1.2	4.27 – 8.92	0.23 (48)
CL_WR
Plasma (L/hr/m²)^*	30.6	31.3	4.46	22.4 – 40.4	0.34 (58)
Plasma (L/hr)	30.1	30.9	4.26	22.4 – 39.4	0.34 (58)
Blood (L/hr/m²)^*	12.5	13.4	2.87	9.6 – 20.5	0.17 (42)
Blood (L/hr)	12.7	13.7	3.1	9.64 – 21	0.15 (39)

Population Parameters with Sex as a Covariate

CL_am
Plasma (L/hr/m²)^*
Male	99	99	8.7	82.6 – 117	0.15 (39)
Δ female	24.2	22.7	9.2	3.7 – 39.4	-
Blood (L/hr/m²)^*
Male	136	133	11.2	112 – 158	0.13 (36)
Δ female	−0.67	−0.08	12.5	−24.7 – 26.5	-
VD
Plasma (L/m²)^*	5.41	5.39	0.56	4.4 – 6.52	0.13 (36)
Blood (L/m²)^*	7.23	6.95	1.1	4.7 – 8.7	0.08 (28)
CL_WR
Plasma (L/m²)^*	31.2	31.9	4.5	23 – 40.8	0.33 (57)
Blood (L/m²)^*	12.5	13.4	2.9	9.7 – 20.9	0.17 (41)

Abbreviations: SEE, standard error of the estimate; 95% CI, percentile bootstrap 95% confidence interval; IIV, interindividual variability; Δ female, population estimated difference in clearance in female patients

indicates estimate from body surface area normalized model