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. Author manuscript; available in PMC: 2011 Jan 15.
Published in final edited form as: Bioorg Med Chem. 2009 Dec 11;18(2):508. doi: 10.1016/j.bmc.2009.12.018

Scheme 2.

Scheme 2

The unusual example of click reaction occuring at both alkynyl groups present on a functionalized chain of an adenosine analogue. When the catalyst TBTA was used, only the monosubstituted product 26 was isolated. Reagents: (i) CuSO4.5H2O, sodium ascorbate, THF/H2O, rt.; (ii) CuSO4.5H2O, sodium ascorbate, TBTA, t-BuOH/H2O, rt.