Table 1. Efficacy of DV-STM-07 vaccine in pregnant mice.
Strain used | No of mice | Death of mother | Mice Aborted/resorption | No of Pups Delivered by surviving mothers | No of pups dead (0-10 Days)/Total no of pups | No of pups dead (10-20 Days)/Total no of pups |
WT Salmonella | 6 | 1 | 3 | 15 | 3/15 | 6/12 ( p-value = 0.004) |
DV-STM-07 | 6 | 0 | 1 | 12 | 3/12 | 0/9 |
PBS | 5 | 0 | 0 | 27 | 7/27 | 0/20 |
Pregnant BALB/c mice were infected with WT and Vaccine strain DV-STM-07 (107 cfu) and were observed for abortion and the offspring outcome. With WT infection, abortion and the death of pups after delivery was more than DV-STM-07 infected mice. The data shows the representative of three independent experiments performed. Fisher's exact test was used to analyze the data. p-values are provided for statistically significant data.