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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Int J Biochem Cell Biol. 2009 Nov 27;42(2):193. doi: 10.1016/j.biocel.2009.11.020

Fig. 1.

Fig. 1

A hypothesis for potential cellular pathways related to the DDR that may participate in angiogenesis. H2AX is important in endothelial cells for supporting endothelial cell proliferation under hypoxic conditions. H2AX is thereby involved in pathological angiogenesis. H2AX interacts with BRCA1 that has been implicated in the regulation of the expression of angiogenic growth factors, as well as in the expression of SIRT1. H2AX phosphorylation may be modulated by HIF-2α, which in turn is deacetylated and regulated by SIRT1. Moreover, SIRT1 regulates the activity of NBS1, a DNA repair factor that interacts with H2AX too. SIRT1 has been shown as a regulator of endothelial cell function and postnatal angiogenesis. Further experimental studies are required to address these hypotheses.