Table 1.

Roles of H2AX, BRCA1 and SIRT1 in DNA repair and angiogenesis^*.

	DNA repair	Angiogenesis
H2AX	- γ-H2AX marker of DNA lesions - promotes DNA repair	- promotes endothelial cell proliferation and pathologic angiogenesis
BRCA1	- binds to DSBs - important for cell cycle progression - deficiency is associated with unrepaired DNA damage and genomic instability	- negative regulation of VEGF and angiopoietin-1 expression
SIRT1	- deacetylates NBS1 - deficiency associated with impaired DNA repair	- promotes endothelial migration and sprouting and postnatal angiogenesis via inhibition of Foxol transcription factor

^*References for these functions of H2AX, BRCA1 and SIRT1 are found in the corresponding text.