Table 3.
Distribution of frequently-mutated genes across GBM subtypes.
| Gene | Proneural (n=37) |
Neural (n=19) |
Classical (n=22) |
Mesenchymal (n=38) |
Total #Mut |
|---|---|---|---|---|---|
| TP53 | 20 (54%) | 4 (21%) | 0 (0%) | 12 (32%) | 36 |
| PTEN | 6 (16%) | 4 (21%) | 5 (23%) | 12 (32%) | 27 |
| NF1 | 2 (5%) | 3 (16%) | 1 (5%) | 14 (37%) | 20 |
| EGFR | 6 (16%) | 5 (26%) | 7 (32%) | 2 (5%) | 20 |
| IDH1 | 11 (30%)* | 1 (5%) | 0 (0%) | 0 (0%) | 12 |
| PIK3R1 | 7 (19%) | 2 (11%) | 1 (5%) | 0 (0%) | 10 |
| RB1 | 1 (3%) | 1 (5%) | 0 (0%) | 5 (13%) | 7 |
| ERBB2 | 2 (5%) | 3 (16%) | 1 (5%) | 1 (3%) | 7 |
| EGFRvIII | 1 (3%) | 0 (0%) | 5 (23%) | 1 (3%) | 7 |
| PIK3CA | 3 (8%) | 1 (5%) | 1 (5%) | 1 (3%) | 6 |
| PDGFRA | 4 (11%) | 0 (0%) | 0 (0%) | 0 (0%) | 4 |
Significance of the difference in number of events between subtypes and remainder of the subtypes was determined using a two sided Fisher’s exact test, corrected for multiple testing using a Family Wise Error Rate. Bolded entries indicate p-values significant at 0.1 level. An asterisk indicates p-values significant at 0.01 level. Also see Figure S5 and Tables S2, S4 and S6.