Skip to main content
. Author manuscript; available in PMC: 2011 Jan 19.
Published in final edited form as: Cancer Cell. 2010 Jan 19;17(1):89. doi: 10.1016/j.ccr.2009.12.008

Figure 4. Myeloid cell IKKβ deletion decreases MTS-induced inflammation and cell proliferation.

Figure 4

(A) Expression of IKKβ in alveolar macrophages of 7-week-old IkkβF/F and IkkβΔmye mice.

(B) BALF cellular composition in air- or MTS-exposed IkkβF/F and IkkβΔmye mice 24 hrs after last MTS exposure. Results are means ± S.E. (IkkβF/F air control: n = 9, IkkβF/F 4 cig./day 2w: n = 9, IkkβΔmye air control: n = 9, IkkβΔmye 4 cig./day 2w: n = 13). Significant difference, *P < 0.03.

(C) Induction of inflammatory cytokine and chemokine mRNAs in lungs of MTS-exposed IkkβF/F and IkkβΔmye mice 24 hrs after last 1 or 2 weeks MTS exposure. Results are means ± S.E. (n = 5 for each group). Significant difference, *P < 0.05.

(D) Secretion of cytokines by lungs of MTS-exposed mice was analyzed as in Fig. 3C. Results are means ± S.E. (IkkβF/F air control: n = 14; IkkβF/F 4 cig./day 2w: n = 8; IkkβΔmye air control: n = 12; IkkβΔmye 4 cig./day 2w: n = 13). Significant difference, *P < 0.04.

(E) Cell proliferation in lungs of air- or MTS-exposed mice was analyzed as in Fig. 3E. Results are means ± S.E. (n = 7 for each group). Significant difference, *P < 0.03. See also Figure S4.