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. Author manuscript; available in PMC: 2011 Jan 19.
Published in final edited form as: Cancer Cell. 2010 Jan 19;17(1):89. doi: 10.1016/j.ccr.2009.12.008

Figure 6. Deletion of JNK1 decreases MTS-induced inflammation, cell proliferation, and lung tumor promotion.

Figure 6

(A) Induction of inflammatory cytokine and chemokine mRNAs in lungs of MTS-exposed Jnk1−/− mice was analyzed as in Fig. 3B. Results are means ± S.E. (n = 5 for each group). Significant difference, *P < 0.05.

(B) Secretion of cytokines in lungs of MTS-exposed Jnk1−/− mice was analyzed as in Fig. 3C. Results are means ± S.E. (WT air control: n = 12; WT 4 cig./day: n = 9; Jnk1−/− air control: n = 9; Jnk1−/− 4 cig./day: n = 9). Significant difference, *P < 0.05.

(C) JNK1 deletion decreases MTS-induced lung cell proliferation. Results are means ± S.E. (WT air control: n = 7; WT 4 cig./day: n = 8; Jnk1−/− air control: n = 10; Jnk1−/− 4 cig./day: n = 9). Significant difference, *P < 0.0003.

(D) Lung appearance (left side) and histology (H&E stain; right side) in 5-month-old K-rasLA2 or K-rasLA2; Jnk1−/− mice with or without MTS exposure.

(E) Lung tumor multiplicity and maximal tumor sizes were determined as in Fig. 2D. Results are means ± S.E. (WT air control: n = 16; WT 4 cig./day: n = 18; Jnk1−/− air control: n = 13; Jnk1−/− 4 cig./day: n = 14). Significant difference, *P < 0.002. See also Figure S6.