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. Author manuscript; available in PMC: 2011 Feb 5.
Published in final edited form as: Circ Res. 2009 Dec 3;106(2):354. doi: 10.1161/CIRCRESAHA.109.207423

Figure 7. Inhibition of SR Ca2+ leak by KN-93 or ryanodine decreases the rate of death in isolated cardiomyocytes from PLN-KO/CaMKII-TG mice.

Figure 7

Isolated cardiomyocytes were plated and incubated in the presence and absence of inhibitors, and cell viability assessed at various times using morphology and at 12 hours by trypan blue exclusion. A, WT myocytes showed only slight decreases in viability over 12 hours after plating. B–C, The percent of living myocytes from both CaMKII-TG and PLN-KO/CaMKII-TG mice decreased dramatically over 12 hours. Inhibition of CaMKII with KN-93 or of SR Ca2+ leak with ryanodine decreased the rate of myocyte death in both CaMKII-TG and PLN-KO/CaMKII-TG mice.