Table 2.
Prediction of head and neck squamous cell carcinoma (HNSCC) and oropharyngeal tumor HPV16 status using demographic and behavioral risk factors and non-tumor biomarkers. Positive predictive value (PPV), negative predictive value (NPV), sensitivity and specificity reported.
| Variables used for prediction* | Oropharyngeal cancers | HNSCC | ||||||
|---|---|---|---|---|---|---|---|---|
| PPV | NPV | Sen | Spec | PPV | NPV | Sen | Spec | |
| Tobacco use, age, gender | 53% | 61% | 84% | 25% | 59% | 66% | 75% | 53% |
| Tobacco use, age, gender, race^ | 55% | 66% | 84% | 31% | 75% | 68% | 76% | 60% |
| HPV16 L1, tobacco use, age, gender, race^ | 59% | 71% | 84% | 40% | 79% | 83% | 63% | 90% |
| HPV16 E6/7, tobacco use, age, gender, race^ | 60% | 75% | 85% | 43% | 73% | 85% | 73% | 85% |
| Oral HPV16 DNA, tobacco, age, gender, race^ | 60% | 77% | 87% | 41% | 83% | 74% | 42% | 97% |
Addition of lifetime number of oral sexual partners, family income, and education to multivariate model did not improve prediction
In these models age was included as a continuous variable, gender was binary, race and ethnicity categories included White non-Hispanic, Black non-Hispanic, and Other which included those of Asian and Middle Eastern race and/or Hispanic ethnicity, pack-years of tobacco were included as a continuous measure, and number of lifetime oral sex partners was in ordinal categories (0,1, 2–5,6–10, 11–15,16–25, 26–50, 51–100, >100)