. Author manuscript; available in PMC: 2010 Feb 10.

Published in final edited form as: Acta Neuropathol. 2009 Mar 14;118(1):131. doi: 10.1007/s00401-009-0517-0

Table 2.

Redox proteomics identification of oxidatively modified proteins in animal models of AD

	Oxidatively modified proteins	Function
Cell culture plus Aβ(1–42)	14-3-3ζ	Signal transduction
Cell culture plus Aβ(1–42)	GAPDH, Pyruvate kinase, Malate dehydrogenase,glutamate dehydrogenase	Energy related
Synaptosomes plus Aβ (1–42)	β and γ-actin, GFAP, DRP-2: H⁺-Transporting two-sector ATPase, syntaxin binding protein, elongation factor tu, Glutamate dehydrogenase	Structural proteins, Energy-related and protein synthesis Excitotoxicity- and Neurotransmission- related
In vivo Aβ(1–42) models	Pyruvate dehydrogenase, GAPDH, Phosphoglycerate mutase-1	Energy related
	GS	Excitotoxicity-and Neurotransmission-related
	Tubulin chain 15/α, β-actin, β-Synuclein	Structural proteins
	14-3-3ζ	Signal transduction
	Chaperonin 60	Mitochondrial and proteosome
C. elegans treated with Aβ(1–42)	Medium-chain and short-chain acyl-CoA dehydrogenase, Translation elongation factor EF-1, Malate dehydrogenase, Arginine kinase	Protein synthesis- and Energy-related
	Proteasome alpha and beta subunits	Proteoasome function
	Glutathione-S-tranferase (GST)	Antioxidant enzymes
	RACK1 ortholog, Adenosine kinase	Signaling proteins
	Lipid binding protein, Transketolase	Lipid metabolism
	Beta actin, Myosin regulatory light chain	Structural proteins
Canine model	GST	Antioxidant enzymes
Canine model	Glutamate dehydrogenase, GAPDH, α-enolase, Fascin actin bundling protein, neurofilament L protein	Energy-, excitotoxic-, neurotransmission-, and structure- related

GFAP glial fibrillary acidic protein, DRP-2 dihydroxypyrimidine related protein-2, GS Glutamine synthetase, GAPDH glyceraldehyde 3-phosphate dehydrogenase