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. Author manuscript; available in PMC: 2011 Jan 15.
Published in final edited form as: Bioorg Med Chem. 2009 Dec 26;18(2):953. doi: 10.1016/j.bmc.2009.11.029

Scheme 1a.

Scheme 1a

aConditions: (a) DMF, 50–60 °C, 72 h; (b) 4-mercaptobenzoic acid, EtOH/H2O (2:1), 100–110 °C, I2; (c) 2-chloro-4,6-dimethoxy-1,3,5-triazine, N-methylmorpholine, diethyl-l-glutamate hydrochloride, 0 °C to r.t.; (d) 1 N NaOH, 0 °C to r.t.; (e) ArSH, I2, 80–90 °C, 4 h (6 and 7); (f) ArSH, 100–110 °C, I2 (8–16).