Skip to main content
. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Bioorg Med Chem Lett. 2010 Jan 4;20(3):841. doi: 10.1016/j.bmcl.2009.12.097

Scheme 2.

Scheme 2

Preparation of fAZT. (a) TrCl, Py, reflux; (b) MsCl, CH2Cl2, 67%; (c) NaOH, EtOH, reflux, 65%; (d) propyne, Pd(PPh3)4, CuI, NEt3, DMF, rt, 22 h, 62%; (e) CuI, NEt3, MeOH, reflux, 70%;(f) MsCl, Et3N, CH2Cl2, rt, 1h, 87%; (g) LiN3, DMF, 110°C, 2.5h, 80%; (h) AcOH, 90°C, 15 min, 60%.