Fig. 3.

Efficacy of ST-246 vs. lethal VV-WR challenge in B cell and/or T cell deficient mice. Immunodeficient mice (as indicated in the legend) and BALB/c mice as controls were intranasally challenged with a 10 × LD₅₀ dose of the wild-type VV-WR on day 0 (n = 5 mice per group). Each immunodeficient mouse model was treated daily with vehicle (dashed lines) or with ST-246 (solid lines) for 14 consecutive days starting at the time of challenge. (A) Survival percentages after challenge. (B) Average weights reported as a percentage of the starting weight. Weight observations were discontinued when animals died (≈70% starting weight) or recovered weight approached 100%. (C) Average disease scores.