Fig. 2.

Nonuniform cable models are required to fit passive experimental voltage transients. (A–C) Voltage responses (black, soma; blue, dendrite) in the somatodendritic recording configuration to brief and long current pulses applied at the soma, superimposed with the prediction of the uniform model (U, red; A), the type 1 nonuniform model (NU1, green; B), and the type 2 nonuniform model (NU2, green; C). Plotting range of the model curves is identical to the fitting range. (D) 3D reconstruction of the same BC shown in A–C and E (BC6; somatodendritic domain in black, axon in red). (E) Semilogarithmic plot of the decay of the long-pulse responses superimposed with the predictions of models (continuous red curve, somatic and dendritic responses for model U; continuous green curve, somatic response for NU2; dashed green curve, dendritic response for NU2). (F) Comparison of SSE values for different models. (G and H) Summary of R_m (G), C_m (H, Left), and R_i (H, Right) of the six BCs fitted with the type 2 nonuniform model (NU2). Bars represent means ± SEMs. Data from individual dual somatic recordings are represented by circles, data from somatodendritic recordings are depicted as triangles. Data from the same cell are connected by lines. Pr, proximal dendritic R_m (R_{m, prox}); Di, distal dendritic R_m (R_{m, dist}); De, weighted average dendritic R_m (R_{m, dend}); Ax, axonal R_m (R_{m, axon}).