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. 2009 Dec 18;107(2):844–849. doi: 10.1073/pnas.0909781107

Fig. 6.

Fig. 6.

 Deletion of TNFRI reduces liver injury, apoptosis, and fibrosis in Tak1ΔHEP mice. WT (n = 10), Tak1ΔHEP (n = 10), Tnfr1−/− (n = 5) and Tnfr1−/− Tak1ΔHEP (n = 7) mice age 1 month were used for the analyses. (A) Expression of TAK1 was determined by immunoblot analysis. (B) Serum ALT levels are shown. (C) Immunoblots of full-length and cleaved caspase-3 are shown. (D) mRNA expression of Tnf, Il1b, Ccl2, Il6, and Timp1 was determined by real-time PCR. (E) Expression of phospho-JNK and JNK in liver was assessed by immunoblot analysis. (F) Collagen deposition was determined by quantification of Sirius red staining. Data are reported as mean ± SEM. *P < .05; **P < .01.