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. Author manuscript; available in PMC: 2011 Feb 3.
Published in final edited form as: J Am Chem Soc. 2010 Feb 3;132(4):1359. doi: 10.1021/ja908562q

Figure 6.

Figure 6

(A) Demonstration that kinetic stabilizers of WT-TTR and V30M-TTR can prevent cytotoxicity associated with the process of TTR amyloidogenesis. IMR-32 human neuroblastoma cells were treated with WT-TTR (8 μM, white bar) or V30M-TTR (8 μM, grey bar) exhibiting cytotoxicity that is prevented by preincubating WT-TTR (white bars) or V30M-TTR (grey bars) with the stilbene and dihydrostilbene-based kinetic stabilizers or resveratrol (1) (a kinetic stabilizer previously shown to be effective) included as a positive control (8 μM each). Cell viability was measured after 24 h by the resazurin reduction assay and all the experimental conditions were compared to cells treated with vehicle only (100% cell viability). (B) Cytotoxicity of selected compounds (8 μM) to the human neuroblastoma cell line IMR-32. Columns represent the average values of 2 independently performed experiments (6 experimental replicates). The error bars represent standard error.