Table 4.

Evaluation of Selected (R)-N-(4-Substituted)benzyl 2-Acetamido-3-methoxypropionamide Derivatives in the Rat Hippocampal Kindled Seizure Model Assay^a

		Preliminary Hippocampal Kindling Test (Rat)				Hippocampal Kindled Rat (0.25 h) (ip)
		Seizure Score		After discharge duration (sec)
No.	R4	Pre-drug	Drug	Pre-drug	Drug	ED50 (mg/kg) (interval)
(R)-17	CH2OCH3	5	0	40 – 69	12	87 (58 – 129)
(R)-20	(CH2)3OCH3	4 – 5	2	21 – 40	21	ND
(R)-21	CH=CH2	4 – 5	0	27 – 43	0–11	ND
(R)-34	N3	4	0	29 – 65	0	6 (3 – 9)
(R)-36	Cl	4 – 5	0	25 – 159	2	ND
(R)-38	I	5	0	17 – 36	0–4	12 (7.5 – 18)
(R)-3b,c	H	5	0	33 – 53	0	14 (9.1 – 18)
phenytoinc		4 – 5	3	42 – 72	51	34 (21 – 45)
phenobarbitalc						20 (14 – 28)
valproatec						210 (150 – 280)

^aThe compounds were tested through the auspices of the NINDS ASP.

^bRef ²³.

^cNINDS ASP internal control data.