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Effect of burst length and contrast agent dose on threshold for biological effects. (a) Effect of burst length on the threshold for blood brain barrier (BBB) disruption. Reproduced with permission from (Mcdannold et al., 2008). (b) Occurrence of petechial hemorrhage as a function of Optison dosage in the mouse intestine and muscle. Reproduced with permission from (Miller and Quddus, 2000).
