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Hypothesized mechanisms of drug transport across endothelium. Illustration of (a) local shear stress created on cell during microbubble oscillation, (b) fluid jet formation, and (c) intra-cellular transport that are hypothesized to result from the stresses induced by microbubble activity, including generation of gaps at tight junctions, expression of cell adhesion molecules due to inflammatory process and the creation of vesicles for trans-cellular transport.
