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. Author manuscript; available in PMC: 2010 Feb 10.
Published in final edited form as: J Biol Chem. 2007 Jun 29;282(38):27578. doi: 10.1074/jbc.M704253200

FIGURE 2. DNA substrates used in this work.

FIGURE 2

Substrates are designed to examine the effect of altering the CpG site context on hTDG activity for the excision of T, U, FU, ClU, and BrU. For the YpG·X substrates, the 5′-flanking pair is varied for G·X substrates. For example, TpG·X indicates that the G·X target pair has a 5′-flanking T·A pair. For the CpA·X substrates, the target base is paired with A rather than G, while the 5′ C·G pair is retained. For the YpA·X substrates, the target base is paired with A and the 5′ flanking base pair is varied.