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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Heart Rhythm. 2009 Oct 12;7(2):199–205. doi: 10.1016/j.hrthm.2009.10.012

Table 1.

Effects of KCNE2 on Kv4.3 and Kv4.3 + KChIP2b

Parameter Kv4.3 Kv4.3
KCNE2 		Kv4.3
KChIP2b		 Kv4.3
KChIP2b KCNE2
Current density at +20 mV (pA/pF) 142.0 ± 16.0
(n = 12)		 66.0 ± 6.6*
(n = 12)		 191.5 ± 33.8
(n = 15)		 77.8 ± 5.9† (n = 20)
Steady-state activation (V0.5 in mV) −6.5 ± 2.1
(n = 9)		 −5.5 ± 1.7
(n = 11)		 −7.5 ± 1.7
(n = 8)		 −7.4 ± 1.4
(n = 8)
Steady-state inactivation (V0.5 in mV) −46.0 ± 1.3
(n = 10)		 −40.8 ± 1.7*
(n = 8)		 −49.8 ± 1.4
(n = 7)		 −44.5 ± 1.9†
(n = 7)
τ of inactivation at +20 mV (τinact in ms) 47.3 ± 2.0
(n = 15)		 87.2 ± 6.2*
(n = 15)		 47.5 ± 2.2
(n = 15)		 66.6 ± 3.5†
(n = 15)
Time to peak at +50 mV (TtP in ms) 4.5 ± 0.2
(n = 20)		 14.4 ± 1.4*
(n = 16)		 4.1 ± 0.2
(n = 15)		 6.1 ± 0.5†
(n = 21)
τ of recovery from inactivation (ms) 419.6 ± 18.8
(n = 6)		 485.6 ± 74.8
(n = 6)		 89.2 ± 5.3
(n = 6)		 60.2 ± 6.9†
(n = 6)
*

Significantly different from Kv4.3.

†

Significantly different from Kv4.3 + KChIP2b.