. Author manuscript; available in PMC: 2010 Feb 10.

Published in final edited form as: J Med Chem. 2009 Feb 26;52(4):916. doi: 10.1021/jm8013234

Table 2.

The log P_oct/water Values, Determined by Using the Shake Flask Method and Analysis by ICP-MS and UV/Visible Spectroscopy, and Cytotoxicity of Complexes 1c–6c Compared to the Mononuclear Complexes 7 and [Ru(cym)(mal)Cl] 8 in SW480 and A2780 Human Cancer Cells, Determined by the MTT Assay

		log P_oct/water		IC₅₀, μM
compd	n	ICP-MS	UV/vis	SW480	A2780
1c	2	−1.42	−1.42	76 ± 4	84 ± 3
2c^a	3	−1.39	−1.40	62 ± 14^a	25 ± 2^a
3c	4	−1.33	−1.38	28 ± 1	41 ± 2
4c^a	6	−1.36	−1.34	26 ± 8^a	30 ± 6^a
5c	8	−1.28	−1.23	2.5 ± 0.2	5.7 ± 0.5
6c^a	12	−0.56	−0.58	0.29 ± 0.05^a	1.5 ± 0.3^a
7				42 ± 1	88 ± 12
[RuCl(cym)(mal)] 8				>100	>100^b

From ref 37.

From ref 39.