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. 2010 Jan 4;29(1):1. doi: 10.1186/1756-9966-29-1

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Copyright ©2010 Zhao et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Tissue distribution of Ad-EGFP-MDR1 in group A. The expression of P-gp (brown staining) in group A on Day 14 after BMT by immunohistochemistry. (A2, B2, C2)×400. In situ hybridization localized Human MDR1 expression in the tissues of group A on Day 14 after BMT. (A1, B1, C1, D) MDR1 DNA was labeled with FITC (green signals). ×1000. P-gp and MDR1 DNA predominantly expressed in intestine (A), lung (B), kidney (C) and the BMCs (D1), but they were not detected in the liver, spleen, brain and tumor tissues. Human MDR1 still could be detected in the BMCs in group A on Day 30 posttreatmen(D2).