Figure 6.
Group data for intracellular recordings at S1. The time ratio of Down state to Up state decreased (A, control), while transition frequency of Up state and the distance of cumulative Vmdistribution increased (B and C, control) in response to nociceptive stimulation. The response of all measures to nociceptive stimulation was not inhibited by parecoxib (left panels, n = 8). Fentanyl (right panels, n = 12) inhibited all responses and naloxone reversed fentanyl's action (n = 9). *P < 0.05, **P < 0.01, #P < 0.001.