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Respiration and sleep become highly fragmented. In the control (pre-injection) period (top), short respiratory disturbances occur infrequently during sleep. On day 7 post-injection, respiratory disturbances occur during REM and NREM, accounting for the highly fragmented sleep pattern and decreased total sleep time. Respiratory disturbances are also more frequent during wakefulness. Data analyzed and plotted in 5-s epochs for one continuous hour of recording.
