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. Author manuscript; available in PMC: 2010 Feb 10.
Published in final edited form as: Acc Chem Res. 2008 Nov 18;41(11):1534. doi: 10.1021/ar800098p

Table 1.

Comparison of the Activity of CyPFtiBu, XPhos, and SIPr for the Reactions of a Heteroaryl Chloride with a Primary Alkylamine.

graphic file with name nihms171385t1.jpg
Entry Pd/L X mol % Pd T [°C] t [h] Conversion
(yield, %)		 A/B
1 Pd(OAc)2/1 0.005 90 24 100(92) 100:0
2 Pd(OAc)2/2 0.05 90 24 40 5.4:1
3 Pd(OAc)2/2 0.1 90 24 85(80) 2.4:1
4 Pd(OAc)2/2 0.5 90 12 88(81) 2.6:1
5 3 0.005 110 24 <10 -
6 3 0.05 110 48 58 >25:1
7 3 0.5 110 12 100(71) 7.6:1