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. Author manuscript; available in PMC: 2010 Feb 10.
Published in final edited form as: Acc Chem Res. 2008 Nov 18;41(11):1534. doi: 10.1021/ar800098p

Table 2.

Comparison of the Activity of CyPFtBu, XPhos, and SIPr for the Reactions of 4-Chlorotoluene with a Primary Alkylamine.

graphic file with name nihms171385t2.jpg
Entry Ligand X mol % Pd/L T [°C] t [h] Conversion (yield, %) A:B
1 Pd(OAc)2/1 0.01 100 48 100(95) 100:0
2 Pd(OAc)2/2 0.05 100 48 13 18:1
3 Pd(dba)2/2 0.1 100 48 25 10:1
4 Pd(dba)2/2 0.5 100 12 100(93) 2.3:1
5 3 0.005 110 48 40 >50:1
6 3 0.05 110 48 76 15.3:1
7 3 0.5 110 12 100 4.3:1