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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Pathol Oncol Res. 2009 Sep;15(3):437–444. doi: 10.1007/s12253-008-9147-4

Fig. 4.

Fig. 4

Hn1 depletion affects growth of GL261 tumors in vivo but not in vitro proliferation rates of GL261 cells. (a) In vitro growth rates of GL261 cells transduced with either Hn1-siRNA AAV6 (grey), control H1 AAV6 (black) at an M.O.I. of 5,000, or no virus (white). There was no difference in the in vitro growth rates of GL261 cells with or without Hn1. (b) Comparison of the growth of in vivo GL261 tumors established from cells pretreated with either control or Hn1-siRNA-expressing AAV6. The scatter-plot shows individual tumor volumes as well as means and SEMs. The difference between the mean volumes of tumors derived from Hn1-expressing and Hn1-depleted cells was statistically significant (p<0.05)