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. Author manuscript; available in PMC: 2010 Feb 10.
Published in final edited form as: J Immunol. 2008 Jul 1;181(1):235. doi: 10.4049/jimmunol.181.1.235

FIGURE 6.

FIGURE 6

PPARγ regulates M-CSF through NF-κB. RAW 264.7 cells were stimulated with LPS, which resulted in a 21.6 ± 0.9-fold increase in M-CSF expression. LPS induced M-CSF expression was reduced by 60 ± 26% when the NF-κB was inhibited with the proteasomal blocker. Pioglitazone treatment also decreased LPS-stimulated M-CSF expression, by 68 ± 15% of the LPS control (p < 0.05 vs LPS alone). The combination of both pioglitazone and NF-κB inhibition resulted in 80 ± 25% reduction of M-CSF expression (p < 0.001 vs LPS). These data suggest that PPARγ can regulate M-CSF induction through repression of NF-κB.