Skip to main content
. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Hypertension. 2010 Jan 4;55(2):233. doi: 10.1161/HYPERTENSIONAHA.109.147256

Figure.

Figure

The role of Syndecan-1 (Synd1) in cardiac fibrosis. Synd1 may act by presenting growth factors to their receptors, may increase TGF-β receptor levels, may promote TGF-β activation, or may activate downstream TGF-β signaling pathways. Understanding the role of syndecan-1 in cardiac injury is complicated by the possible presence of shed ectodomains (released due to increased Matrix Metalloproteinase [MMP] activity), that may sequester growth factors, or promote chemotactic gradients (Ang II, angiotensin II).