Table 1.
L | Ligand | 5:6[b] | Yeld [%] | ee [%][c] |
---|---|---|---|---|
L1 | R1 = Ph | 91:9 | 73 | 95 |
L2 | R1 = 2-anisyl | 95:5 | 62 | 99 |
L3 | R1 = 1-Np | 87:13 | 64 | 91 |
L4 | R2 = Ph | 90:10 | 64 | 91 |
L5 | R2 = 2-anisyl | 82:8 | 59 | 89 |
L6 | R2 = 1-Np | 88:12 | 60 | 71 |
All ratios of 5:6, isolated yields and ee or de values are averages from two independent runs.
Ratio of 5:6 determined by 1H NMR analysis of the crude reaction mixture.
Determined by HPLC.