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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Annu Rev Med. 2010;61:153. doi: 10.1146/annurev.med.042508.093728

Figure 1. Overlapping epitopes.

Figure 1

Three well characterized HIV-1 epitopes (B*57 TW10, B*57 IW9, A*02 SL9) are shown in the context of overlapping epitopes that have been described in the literature. The compensatory mutations for the B*57 TW10 escape mutation T242N (92) are also shown embedded in overlapping epitopes to further illustrate the complexity at the population level of these immunologic targets. The epitopes that have been described in the literature are likely only the tip of the iceberg, since reagents used to screen for epitopes are seldom based on autologous sequences, which would enable detection of novel epitopes that are specific for less common variants. The common HLA molecules are in bold.