Table 1. HIV-1 vaccine efficacy studies.
Vaccine Concept | Developer | Study | Status |
---|---|---|---|
1. monomeric gp120 (B/B, B/E) | VaxGen | VAX 003, VAX 004 (phase 3) | completed in 2003 (42, 43) |
2. rAd5-Gag/Pol/Nef | Merck | HVTN 502 “STEP” (phase 2b) | stopped in 2007 (49) |
3. ALVAC (vCP1521) prime, gp120 (B/E) boost | Sanofi, VaxGen | RV 144 (phase 3) | will be completed in 2009 |
4. DNA prime, rAd5 boost Gag/Pol/EnvA/EnvB/EnvC | NIH VRC | HVTN 505 (phase 2) | scheduled to begin in 2009 |