Table 3.

Polymorphic Variants of the MPDZ Gene Selected for LD and Haplotype Analysis

			Minor allele frequency			No AWSa versus Coriellb			AWS versus Alcoholicb
dbSNP ID	Variant	Location	AWS	No AWSa	Coriell	p value	OR	95% CI	p value	OR	95% CI
N/A	insT	−436 upstream	0.197	0.246	0.234	0.882	1.064	0.567–1.994	0.437	0.752	0.388–1.450
rs13297480	A > G	Exon 7	0.090	0.203	0.094	0.019	2.459	1.113–5.701	0.017	0.390	0.163–0.878
rs2274856	G > A	Exon 19	0.205	0.305	0.273	0.673	0.858	0.475–1.546	0.078	1.700	0.909–3.218
rs1331674	G > A	Intron 19	0.213	0.297	0.273	0.777	0.893	0.494–1.614	0.142	1.554	0.832–2.930
rs3831219	delCTC	Intron 20	0.254	0.339	0.336	1.000	1.014	0.577–1.780	0.160	0.665	0.365–1.204
rs1331672	C > G	Intron 21	0.230	0.322	0.336	0.892	0.939	0.532–1.655	0.114	0.628	0.339–1.154
rs10756457	A > G	Exon 24	0.238	0.347	0.336	0.893	1.052	0.600–1.845	0.066	0.587	0.320–1.067
rs7024892	A > G	Intron 24	0.238	0.364	0.328	0.593	1.173	0.670–2.055	0.035	0.545	0.298–0.988
rs2297003	A > G	Intron 34	0.246	0.339	0.336	1.000	0.987	0.562–1.734	0.120	1.570	0.864–2.873
rs2274647	A > C	Intron 38	0.270	0.364	0.313	0.420	1.260	0.718–2.217	0.129	0.648	0.360–1.159
rs3765550	A > G	Intron 45	0.443	0.373	0.406	0.603	0.870	0.503–1.499	0.295	1.334	0.772–2.315
rs3264	A > G	Exon 46	0.369	0.424	0.336	0.188	1.451	0.838–2.522	0.429	0.796	0.458–1.379
rs722651	C > T	Intron 46	0.361	0.263	0.383	0.056	0.576	0.321–1.023	0.125	1.580	0.880–2.862

AWS, group of alcoholic subjects with a history of withdrawal seizure; OR, odd ratio; CI, confidence intervals.

^aNo AWS group included alcohol-dependent subjects without history of withdrawal seizure and/or delirium tremens.

^bStatistical analyses were performed using Fisher’s exact test.

p values below 0.05 are presented in bold.