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CD8 null tetramers distinguish CD8 T cell clones of high and low sensitivity. (a) CD8 T cell clones able to bind CD8 null tetramers have high functional sensitivity. (b) Low-avidity clones unable to bind CD8 null tetramers have low functional sensitivity. (c) ‘Functional avidity’ or sensitivity assays distinguish sensitivity of CD8 T cell clones that are able and unable to bind CD8 null tetramers.
