Table 1.
Summary of clinical and serological findings for each autoimmune disease.
| Age (years) |
Total PBDCs/ml |
Myeloid DCs/ml |
Plasmacytoid DCs/ml |
WBCs/µl |
ANA log titre |
RF IU/ml |
Anti-SSA |
Anti-SSB |
|||
|---|---|---|---|---|---|---|---|---|---|---|---|
| n | Sex (M/F) | Mean range | Mean range | Mean range | Mean range | Mean range | Positive/n range | Positive/n range | Positive/n | Positive/n | |
| Normal | 32 | 12/20 | 48·0 | 19 380 | 12 356 | 7 105 | 4 822 | 0/32 | 0/32 | 0/32 | 0/32 |
| 25–72 | 12 009–32 708 | 7 090–21 760 | 3 356–12 270 | 3 800–10 200 | – | – | |||||
| SLE | 11 | 2/9 | 25·3 | 9 749 | 4 876 | 4 873 | 3 864 | 11/11 | n.d. | n.d. | n.d. |
| 14–66 | 3 179–22 464 | 563–15 298 | 2 313–8 240 | 1 900–8 400 | 20–2,560 | ||||||
| SSc | 14 | 1/13 | 54·9 | 17 738 | 10 655 | 7 083 | 5 371 | 11/12 | n.d. | n.d. | n.d. |
| 41–67 | 7 399–23 855 | 2 862–15 345 | 2 216–13 676 | 3 400–8 300 | < 20–1,280 | ||||||
| RA | 12 | 3/9 | 55·9 | 19 437 | 11 738 | 7 699 | 8 650 | n.d. | 8/12 | n.d. | n.d. |
| 30–79 | 10 987–32 019 | 4 776–26 655 | 2 673–16 505 | 4 500–12 600 | < 20–828 | ||||||
| Primary SS | 29 | 2/27 | 58·6 | 11 719 | 5 265 | 6 460 | 5 224 | 29/29 | 15/29 | 27/29 | 11/29 |
| 29–76 | 4 213–24 786 | 1 441–15 900 | 2 416–13 271 | 2 900–9 100 | 20–1280 | < 20–244 | |||||
| Secondary SS | 24 | 2/22 | 55·5 | 14 548 | 7 312 | 7 236 | 5 704 | 21/24 | 12/24 | 21/24 | 5/24 |
| 28–72 | 1 243–25 982 | 286–15 081 | 957–15 427 | 2 800–11 300 | < 20–1280 | < 20–760 | |||||
| Secondary SS with SLE | 5 | 1/4 | 39·0 | 6 358 | 2 863 | 3 495 | 3 900 | 5/5 | 1/5 | 5/5 | 2/5 |
| 30–50 | 1 243–13 665 | 286–7 599 | 957–6 066 | 2 900–5 300 | 160–1,280 | < 20–39 | |||||
| Secondary SS with SSc | 8 | 0/8 | 63·1 | 17 855 | 8 959 | 8 897 | 5 550 | 7/8 | 1/8 | 5/8 | 1/8 |
| 50–72 | 13 003–24 256 | 4 876–14 135 | 4 821–15 427 | 3 100–8 500 | < 20–320 | < 20–65 | |||||
| Secondary with RA | 11 | 1/10 | 57·5 | 15 866 | 8 137 | 7 729 | 6 636 | 9/11 | 10/11 | 10/11 | 2/11 |
| 28–69 | 8 526–25 982 | 2 065–15 081 | 4 220–10 998 | 2 800–11 300 | < 20–640 | < 20–760 |
Normal values are as follows: white blood cells (WBCs) 3000–8500, anti-nuclear antibodies (ANA) < 20, rheumatoid factor (RF) < 20, and anti-Sjögren's syndrome antigen A (SSA) and anti-SSB negative. PBDCs: peripheral blood dendritic cells. Absolute numbers (per ml) of PBDCs were calculated by multiplying the percentage contributed by the lineage marker-negative, human leucocyte antigen D-related (HLA-DR+) fraction to the total number of flow cytometry events by count (per ml) of peripheral blood mononuclear cells (PBMCs) after negative selection; M/F: male/female; n.d.: not done.