Table 1.

Patient characteristics.

Patient no.	Sex	Age at dx: years	Total IgG: mg/dl*	IgG3: mg/dl (normal range)	Clinical presentation	Other diagnoses
1	F	41	794	11 (41–129)	URIs, 4 PNs as a child, Lyme disease	AR, asthma
2	M	24	801	23 (41–129)	Recurrent URIs since childhood
3	F	47	1005	10 (41–129)	URIs, sinusitis, 2 PNs	AR, sister with low IgG3
4	F	71	803	34 (41–129)	URIs, PNs	AR, rheumatoid arthritis
5	M	55	968	19 (21–114)	Rash on legs (biopsy: many eosinophils)	High IgE
6	F	62	1070	17 (21–114)	Recurrent URIs
7	F	63	876	20 (21–114)	Recurrent URIs	Asthma, multiple drug allergies
8	F	56	760	27 (41–129)	URIs, sinusitis, 2 PNs, hospitalizations	AR, asthma, Grave's disease, temporal arteritis
9	F	57	1120	20 (21–114)	Recurrent URIs, recurrent anaphylactoid urticaria	AR, asthma
10	F	45	966	13 (41–129)	Recurrent URIs, recurrent herpes infections, interstitial cystitis	AR, psoriasis
11	M	32	1120	23 (41–129)	Recurrent sinusitis, chronic fungal infection of skin and prostate
12	F	25	808	20 (41–129)	Recurrent URIs and sinusitis	AR
13	M	17	747	28 (41–129)	Childhood infections, 2 PNs	AR
14	F	61	1300	17 (21–114)	Multiple sinus infections and surgeries (Pseudomonas on culture), bronchitis, hospitalizations	Non-Hodgkin's lymphoma (diagnosed 3 years after IgG3 deficiency diagnosis)
15	F	36	818	19 (21–114)	Recurrent URIs, sinusitis	AR, polyneuritis
16	F	53	1190	16 (21–114)	Chronic fatigue
17	F	41	1481	14 (21–114)	Recurrent URIs and sinusitis, severe CMV and EBV infections

^*Normal range for total immunoglobulin G (IgG): 700–1600 mg/dl. Description of each patient's age, sex, total IgG, IgG3 subclass, presenting complaints and other associated diagnoses; dx, diagnosis; M: male; F: female; URI: upper respiratory infection; PN: pneumonia; AR: allergic rhinitis; CMV: cytomegalovirus; EBV: Epstein–Bar virus.