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. Author manuscript; available in PMC: 2010 Feb 10.
Published in final edited form as: Annu Rev Anal Chem (Palo Alto Calif). 2008 Jul 1;1:329. doi: 10.1146/annurev.anchem.1.031207.113038

Figure 2.

Figure 2

Measurements of serotonin overflow from enterochromaffin cells at adult or neonatal guinea pig ileum tissue. (a) Current versus time trace of serotonin overflow from adult guinea pig ileum tissue recorded with a diamond electrode (solid line) and carbon fiber electrode (dotted line). (b) Current versus time trace of serotonin overflow recorded with a diamond electrode for normal response (solid line) and in the presence of serotonin transporter (SERT) antagonist, fluoxetine (dotted line) for adult guinea pig ileum tissue. The current increased dramatically in the presence of fluoxetine, signifying that the measured current was indeed serotonin. (c) Current versus time trace of serotonin overflow recorded from neonatal guinea pig ileum tissue (dark blue) and the same tissue in the presence of fluoxetine (light blue). No difference in current profile was noted, suggesting that SERT activity in neonates is significantly low or underdeveloped as compared with adult. Abbreviations: OTc, over tissue current; TTc, touching tissue current. Panels a and b reproduced from Reference 53 with permission. Panel c reproduced from Reference 54 with permission.