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. Author manuscript; available in PMC: 2011 Feb 16.
Published in final edited form as: Biochemistry. 2010 Feb 16;49(6):1127. doi: 10.1021/bi901994d

Fig. 1. MT1-MMP and MMP2 are expressed in regions of fibrillar Aβ accumulation in Tg-SwDI mouse brain.

Fig. 1

Brain sections from twenty four month old Tg-SwDI mice were labeled for fibrillar Aβ using Th-S (green) showing that the cortex (A) lacks appreciable fibrillar amyloid whereas the thalamic region (B) contains extensive microvascular amyloid accumulations. Immunolabeling for MMP2 or MT1-MMP (red) in adjacent brains sections shows weak expression in the cortex (C and E, respectively) but strong expression in the thalamic region (D and F, respectively) containing abundant microvascular amyloid. Scale bars = 50 μm.