Adjacent 5 μm fresh frozen brain sections from 18 months old Tg2576 mice were incubated alone (A,B,C,E) or with purified MTIdTM (D) or GM6001-treated MT1dTM (F) at 37°C for 5 days. The sections were then fixed, and stained with Th-S. Insets show parallel representative plaques enlarged. Scale bars = 50 μm. (G) The parallel cortical fibrillar amyloid plaque areas were quantified in the treated and untreated sections and expressed as percent remaining Th-S area. The data presented are the mean ± S.D. of n = 25 plaques (buffer alone); n = 37 plaques (incubated with MT1dTM); n = 27 plaques (incubated with GM6001-treated MT1dTM). *, p < 0.001, paired t test.