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SB-334867 attenuated cocaine-seeking elicited by cues or following abstinence. Pretreatment with SB-334867 (20 mg/kg, ip) significantly reduced cue-induced reinstatement of extinguished lever-pressing as compared to vehicle pretreatment in the same animals (*p < 0.01). Pretreatment with SB-334867 also significantly reduced lever-pressing (cocaine-seeking) following 2 weeks of abstinence from cocaine self-administration as compared to animals given vehicle (**p < 0.005).
