Figure 4.

SB-334867 (30 mg/kg, ip) attenuated reinstatement elicited by contextual stimuli in an ABA (renewal) design. Animals were trained to self-administer cocaine in a distinct context and then given extinction training in an alternate environment. In a within-subjects design, rats were pretreated with SB (30 mg/kg, i.p.) or vehicle prior to re-exposure to the original self-administration context. Mean (± SEM) number of presses on the active and inactive lever in a 2-hour reinstatement session in the self-administration chamber is shown. a, Active lever responding during context-induced reinstatement of extinguished cocaine-seeking was significantly attenuated by SB (n = 9), as compared to vehicle (*p < 0.001). b, Inactive lever responding was not significantly affected by SB pretreatment. The apparent decrease in responding on the inactive lever is expected if SB attenuates drug-seeking.