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. Author manuscript; available in PMC: 2011 Feb 15.
Published in final edited form as: Arch Biochem Biophys. 2009 Dec 11;494(2):107. doi: 10.1016/j.abb.2009.12.005

Figure 4.

Figure 4

Reaction of butyrylcholinesterase and acetylcholinesterase with OP. 1) formation of reversible complex; 2) phosphylation of the active site serine, with departure of the leaving group X and inversion of the stereochemistry of the OP; 3) reactivation of phosphylated enzyme by oximes or by 2 M potassium fluoride; 4) aging to produce a negatively charged OP stabilized by interaction with the positively charged histidine of the catalytic triad. Inset. When the OP is soman, R1 is pinacolyl alcohol. Dealkylation does not yield pinacolyl alcohol, but instead yields 3 rearranged products [75].